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About Cryo-EM

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Cryogenic electron microscopy (cryo-EM) and cryogenic electron tomography (cryo-ET) are powerful methods for revealing the structural components of the living world utilizing electron microscopes and electron detectors that enable researchers to see beyond the reach of traditional light and confocal microscopy. By mapping the structure of molecules and how they interact with each other, we hope to understand their function in larger biological systems. Applications of cryo-EM have led to impactful discoveries in understanding disease, cellular function, virology, drug discovery and more.

The cryo-EM facility at UC San Diego is dedicated to providing the tools and expertise necessary to facilitate the study of cellular and macromolecular structures through use of single-particle and tomographic techniques.

Our mission is to provide the UCSD community access to high-end state of the art instrumentation, to maximize the scientific impact of this instrumentation, and to foster the development of a robust cryo-EM community.

 

Facility Updates

The facility is currently operating at a reduced capacity in accordance with the University Orange Phase Research Ramp Up. Please visit the facility’s COVID-19 page for our operational changes. Certain one-on-one training is temporarily suspended.

During the 2020 holiday season, the cryo-EM facility will officially close on December 24-25 and be limited for use up to Friday, January 4, 2021 with no facility staff readily available. Contact the facility manager if you will be working during this period.

Facility Online Manager (FOM)

Use the Facility Online Manager to schedule your equipment use.

Learn about FOM

Getting Started

Learn how to become a new user and begin working with the Cryo-Em equipment.

Onboarding Process

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